Vaginal myeloid dendritic cells transmit founder HIV-1
R Shen, JC Kappes, LE Smythies, HE Richter… - Journal of …, 2014 - Am Soc Microbiol
R Shen, JC Kappes, LE Smythies, HE Richter, L Novak, PD Smith
Journal of virology, 2014•Am Soc MicrobiolWe report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and
express CD4, CCR5, and CXCR4. Vaginal CD13+ CD11c+ DCs rapidly and efficiently
bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through
explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes.
Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in
vivo and are candidate “gatekeeper” cells in HIV-1 transmission.
express CD4, CCR5, and CXCR4. Vaginal CD13+ CD11c+ DCs rapidly and efficiently
bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through
explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes.
Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in
vivo and are candidate “gatekeeper” cells in HIV-1 transmission.
Abstract
We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13+ CD11c+ DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate “gatekeeper” cells in HIV-1 transmission.
American Society for Microbiology