Crescent formation in glomerulonephritis (GN) is a manifestation of severe glomerular injury
that usually results in a poor clinical outcome. In humans, crescentic GN is frequently
associated with evidence of either systemic or organ-specific autoimmunity. T cells play a
major role in initiation of adaptive immune responses that lead to crescentic injury. In
experimental models of crescentic GN, Th1 predominant immune responses have been
shown to promote crescent formation. Perturbation of regulatory T cell function may …