[HTML][HTML] The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae
H Fang, S Panzner, C Mullins, E Hartmann… - Journal of Biological …, 1996 - ASBMB
The multisubunit signal peptidase catalyzes the cleavage of signal peptides and the
degradation of some membrane proteins within the endoplasmic reticulum (ER). The only
subunit of this enzyme functionally examined to date, yeast Sec11p, is related to signal
peptidase I from bacteria. Since bacterial signal peptidase is capable of processing both
prokaryotic and eukaryotic signal sequences as a monomer, it is unclear why the analogous
enzyme in the ER contains proteins unrelated to signal peptidase I. To address this issue …
degradation of some membrane proteins within the endoplasmic reticulum (ER). The only
subunit of this enzyme functionally examined to date, yeast Sec11p, is related to signal
peptidase I from bacteria. Since bacterial signal peptidase is capable of processing both
prokaryotic and eukaryotic signal sequences as a monomer, it is unclear why the analogous
enzyme in the ER contains proteins unrelated to signal peptidase I. To address this issue …