Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model
K Roy, D Hamilton, MM Ostmann, JM Fleckenstein - Vaccine, 2009 - Elsevier
K Roy, D Hamilton, MM Ostmann, JM Fleckenstein
Vaccine, 2009•ElsevierEnterotoxigenic Escherichia coli (ETEC) remain a leading cause diarrheal illness, prompting
a search for vaccine targets that lead to the recent discovery of EtpA, a secreted adhesin of
ETEC that acts by bridging flagella and host cells. In a murine model, immunization with
recombinant EtpA glycoprotein inhibited colonization by two EtpA-producing human ETEC
strains, H10407 and E24377A. In addition, vaccination with recombinant flagellin (serotype
H11) generated antibodies that specifically recognized the tips of flagella from E24377A …
a search for vaccine targets that lead to the recent discovery of EtpA, a secreted adhesin of
ETEC that acts by bridging flagella and host cells. In a murine model, immunization with
recombinant EtpA glycoprotein inhibited colonization by two EtpA-producing human ETEC
strains, H10407 and E24377A. In addition, vaccination with recombinant flagellin (serotype
H11) generated antibodies that specifically recognized the tips of flagella from E24377A …
Enterotoxigenic Escherichia coli (ETEC) remain a leading cause diarrheal illness, prompting a search for vaccine targets that lead to the recent discovery of EtpA, a secreted adhesin of ETEC that acts by bridging flagella and host cells. In a murine model, immunization with recombinant EtpA glycoprotein inhibited colonization by two EtpA-producing human ETEC strains, H10407 and E24377A. In addition, vaccination with recombinant flagellin (serotype H11) generated antibodies that specifically recognized the tips of flagella from E24377A expressing a heterologous flagellar serotype (H28) and afforded significant protection against colonization. EtpA and/or flagellin could be valuable subunit antigens in the formulation of a broadly protective ETEC vaccine.
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