The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice
C Libert, S Van Bladel, P Brouckaert… - Journal of …, 1991 - journals.lww.com
In this study, we investigated the influence of D-galactosamine (GalN), indomethacin, and
dexamethasone on the pharmacokinetics of injected or induced tumor necrosis factor (TNF)
and interleukin-6 (IL-6) after a bolus injection of murine TNF (mTNF) or lipopolysaccharide
(LPS). It is well known that GalN treatment renders mice much more vulnerable to TNF or
LPS lethality. Nevertheless, GalN had no influence on TNF clearance or IL-6 induction after
mTNF injection; however, the induced TNF and IL-6 levels were considerably augmented by …
dexamethasone on the pharmacokinetics of injected or induced tumor necrosis factor (TNF)
and interleukin-6 (IL-6) after a bolus injection of murine TNF (mTNF) or lipopolysaccharide
(LPS). It is well known that GalN treatment renders mice much more vulnerable to TNF or
LPS lethality. Nevertheless, GalN had no influence on TNF clearance or IL-6 induction after
mTNF injection; however, the induced TNF and IL-6 levels were considerably augmented by …