Reduction of nerve growth factor level in the brain of genetically ataxic mice (weaver, reeler)
K Matsui, S Furukawa, H Shibasaki, T Kikuchi - FEBS letters, 1990 - Elsevier
K Matsui, S Furukawa, H Shibasaki, T Kikuchi
FEBS letters, 1990•ElsevierBy a highly sensitive enzyme immunoassay we measured the level of nerve growth factor
(NGF) in the cerebellum and cerebrum of the neurologically mutant mice, weaver, reeler and
Purkinje cell degeneration (PCD). A significant decrease in NGF level was observed in both
cerebellum and cerebrum of weaver and reeler mutants of either sex. However, there was
no such difference between normals and mutants in the case of the PCD mice. These results
show that weaver and reeler mice have abnormalities of NGF synthesis and/or degradation …
(NGF) in the cerebellum and cerebrum of the neurologically mutant mice, weaver, reeler and
Purkinje cell degeneration (PCD). A significant decrease in NGF level was observed in both
cerebellum and cerebrum of weaver and reeler mutants of either sex. However, there was
no such difference between normals and mutants in the case of the PCD mice. These results
show that weaver and reeler mice have abnormalities of NGF synthesis and/or degradation …
Abstract
By a highly sensitive enzyme immunoassay we measured the level of nerve growth factor (NGF) in the cerebellum and cerebrum of the neurologically mutant mice, weaver, reeler and Purkinje cell degeneration (PCD). A significant decrease in NGF level was observed in both cerebellum and cerebrum of weaver and reeler mutants of either sex. However, there was no such difference between normals and mutants in the case of the PCD mice. These results show that weaver and reeler mice have abnormalities of NGF synthesis and/or degradation not only in the cerebellum but also in the cerebrum.
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