The influence of steroid metabolism on CYP17A1 inhibitor activity
F Claessens, L Moris - Nature Reviews Urology, 2017 - nature.com
F Claessens, L Moris
Nature Reviews Urology, 2017•nature.comGaleterone is a steroid 17-α-hydroxylase/17, 20 lyase and androgen receptor antagonist
intended for patients with prostate cancer. Similar to abiraterone, galeterone has a steroid
scaffold structure and mimics natural ligands; thus, these agents are metabolized by the
same enzymes that synthesize or degrade naturally occurring steroids, which can result in
attenuated efficacy.
intended for patients with prostate cancer. Similar to abiraterone, galeterone has a steroid
scaffold structure and mimics natural ligands; thus, these agents are metabolized by the
same enzymes that synthesize or degrade naturally occurring steroids, which can result in
attenuated efficacy.
Galeterone is a steroid 17-α-hydroxylase/17,20 lyase and androgen receptor antagonist intended for patients with prostate cancer. Similar to abiraterone, galeterone has a steroid scaffold structure and mimics natural ligands; thus, these agents are metabolized by the same enzymes that synthesize or degrade naturally occurring steroids, which can result in attenuated efficacy.
nature.com
