CD4 T cell help is critical for the generation and maintenance of germinal centers (GCs), and T follicular helper (T FH) cells are the CD4 T cell subset required for this process. Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP [SH2D1A]) expression in CD4 T cells is essential for GC development. However, SAP-deficient mice have only a moderate defect in T FH differentiation, as defined by common T FH surface markers. CXCR5+ T FH cells are found within the GC, as well as along the boundary regions of T/B cell zones. In this study, we show that GC-associated T follicular helper (GC T FH) cells can be identified by their coexpression of CXCR5 and the GL7 epitope, allowing for phenotypic and functional analysis of T FH and GC T FH populations. GC T FH cells are a functionally discrete subset of further polarized T FH cells, with enhanced B cell help capacity and a specialized ability to produce IL-4 in a T H 2-independent manner. Strikingly, SAP-deficient mice have an absence of the GC T FH cell subset and SAP− T FH cells are defective in IL-4 and IL-21 production. We further demonstrate that SLAM (Slamf1, CD150), a surface receptor that uses SAP signaling, is specifically required for IL-4 production by GC T FH cells. GC T FH cells require IL-4 and-21 production for optimal help to B cells. These data illustrate complexities of SAP-dependent SLAM family receptor signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T cells but not in T FH cell and GC T FH cell differentiation.