The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

SS McAllister, RA Weinberg - Nature cell biology, 2014 - nature.com
Nature cell biology, 2014nature.com
Recent pre-clinical and clinical research has provided evidence that cancer progression is
driven not only by a tumour's underlying genetic alterations and paracrine interactions within
the tumour microenvironment, but also by complex systemic processes. We review these
emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of
systemic regulation of cancer progression could guide development of new therapeutic
modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
Abstract
Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
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