Neonatal Fc receptor stimulation induces ubiquitin c-terminal hydrolase-1 overexpression in podocytes through activation of p38 mitogen-activated protein kinase
H Gan, S Feng, H Wu, Y Sun, R Hu, Z Zhao, Z Zhang - Human pathology, 2012 - Elsevier
Ubiquitin c-terminal hydrolase-1 is overexpressed in renal podocytes in some immune
complex-mediated glomerulonephritides, an effect closely related to extensive podocyte
injury. Neonatal Fc receptor is newly recognized to be present on human renal podocytes. It
is presumed that neonatal Fc receptor serves as a sensor for immune stimulation
transduction and is involved in the pathogenesis of podocyte injury. In our current study, we
found that neonatal Fc receptor was constitutively expressed in normal podocytes and up …
complex-mediated glomerulonephritides, an effect closely related to extensive podocyte
injury. Neonatal Fc receptor is newly recognized to be present on human renal podocytes. It
is presumed that neonatal Fc receptor serves as a sensor for immune stimulation
transduction and is involved in the pathogenesis of podocyte injury. In our current study, we
found that neonatal Fc receptor was constitutively expressed in normal podocytes and up …