[HTML][HTML] The effect of blood coagulation factor XIII on fibrin clot structure and fibrinolysis
EL Hethershaw, ALC La Corte, C Duval, M Ali… - Journal of Thrombosis …, 2014 - Elsevier
Background Factor XIII is a 320 kDa tetramer, comprising two enzymatic A‐subunits and two
carrier B‐subunits (FXIII A 2 B 2). Activated FXIII (FXIIIa) catalyses the formation of ε‐(γ‐
glutamyl) lysyl covalent bonds between γ‐γ, γ‐α and α‐α chains of adjacent fibrin molecules
and also cross‐links the major plasmin inhibitor, α2‐antiplasmin, to fibrin. Objectives We
investigated the role of FXIII cross‐linking of fibrin directly in clot morphology and its
functional effect on clot formation and lysis, in the absence of α2‐antiplasmin. Results and …
carrier B‐subunits (FXIII A 2 B 2). Activated FXIII (FXIIIa) catalyses the formation of ε‐(γ‐
glutamyl) lysyl covalent bonds between γ‐γ, γ‐α and α‐α chains of adjacent fibrin molecules
and also cross‐links the major plasmin inhibitor, α2‐antiplasmin, to fibrin. Objectives We
investigated the role of FXIII cross‐linking of fibrin directly in clot morphology and its
functional effect on clot formation and lysis, in the absence of α2‐antiplasmin. Results and …