Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution
CN Serhan - Prostaglandins, leukotrienes and essential fatty acids, 2005 - Elsevier
Lipoxins (LXs) or the lipoxygenase interaction products are generated from arachidonic acid
via sequential actions of lipoxygenases and subsequent reactions to give specific
trihydroxytetraene-containing eicosanoids. These unique structures are formed during cell–
cell interactions and appear to act at both temporal and spatially distinct sites from other
eicosanoids produced during the course of inflammatory responses and to stimulate natural
resolution. Lipoxin A4 (LXA4) and lipoxin B4 (LXB4) are positional isomers that each …
via sequential actions of lipoxygenases and subsequent reactions to give specific
trihydroxytetraene-containing eicosanoids. These unique structures are formed during cell–
cell interactions and appear to act at both temporal and spatially distinct sites from other
eicosanoids produced during the course of inflammatory responses and to stimulate natural
resolution. Lipoxin A4 (LXA4) and lipoxin B4 (LXB4) are positional isomers that each …