[HTML][HTML] Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection
A Asatryan, NG Bazan - Journal of Biological Chemistry, 2017 - ASBMB
Docosahexaenoic acid, enriched in the brain and retina, generates docosanoids in
response to disruptions of cellular homeostasis. Docosanoids include neuroprotectin D1
(NPD1), which is decreased in the CA1 hippocampal area of patients with early-stage
Alzheimer's disease (AD). We summarize here how NPD1 elicits neuroprotection by up-
regulating c-REL, a nuclear factor (NF)-κB subtype that, in turn, enhances expression of
BIRC3 (baculoviral inhibitor of apoptosis repeat-containing protein 3) in the retina and in …
response to disruptions of cellular homeostasis. Docosanoids include neuroprotectin D1
(NPD1), which is decreased in the CA1 hippocampal area of patients with early-stage
Alzheimer's disease (AD). We summarize here how NPD1 elicits neuroprotection by up-
regulating c-REL, a nuclear factor (NF)-κB subtype that, in turn, enhances expression of
BIRC3 (baculoviral inhibitor of apoptosis repeat-containing protein 3) in the retina and in …