Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial
CE Ramsden, KR Faurot, D Zamora, CM Suchindran… - PAIN®, 2013 - Elsevier
Abstract Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with
antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded,
parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in
dietary n-3 and n-6 fatty acids for treatment of chronic headaches. After a 4-week
preintervention phase, ambulatory patients with chronic daily headache undergoing usual
care were randomized to 1 of 2 intensive, food-based 12-week dietary interventions: a high …
antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded,
parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in
dietary n-3 and n-6 fatty acids for treatment of chronic headaches. After a 4-week
preintervention phase, ambulatory patients with chronic daily headache undergoing usual
care were randomized to 1 of 2 intensive, food-based 12-week dietary interventions: a high …