[HTML][HTML] Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury
O Eickmeier, H Seki, O Haworth, JN Hilberath, F Gao… - Mucosal …, 2013 - Elsevier
Acute lung injury (ALI) is a severe illness with excess mortality and no specific therapy.
Protective actions were recently uncovered for docosahexaenoic acid-derived mediators,
including D-series resolvins. Here, we used a murine self-limited model of hydrochloric acid-
induced ALI to determine the effects of aspirin-triggered resolvin D1 (AT-RvD1; 7S, 8R, 17R-
trihydroxy-4Z, 9E, 11E, 13Z, 15E, 19Z-docosahexaenoic acid) on mucosal injury. RvD1 and
its receptor ALX/FPR2 were identified in murine lung after ALI. AT-RvD1 (∼ 0.5–5 μg kg− 1) …
Protective actions were recently uncovered for docosahexaenoic acid-derived mediators,
including D-series resolvins. Here, we used a murine self-limited model of hydrochloric acid-
induced ALI to determine the effects of aspirin-triggered resolvin D1 (AT-RvD1; 7S, 8R, 17R-
trihydroxy-4Z, 9E, 11E, 13Z, 15E, 19Z-docosahexaenoic acid) on mucosal injury. RvD1 and
its receptor ALX/FPR2 were identified in murine lung after ALI. AT-RvD1 (∼ 0.5–5 μg kg− 1) …