The discovery of an increasing number of histone demethylases has highlighted the
dynamic nature of the regulation of histone methylation, a key chromatin modification that is
involved in eukaryotic genome and gene regulation. A flurry of recent studies has offered
glimpses into the specific biological roles of these enzymes and their potential connections
to human diseases. These advances have also catalysed a resurgence of interest in
epigenetic regulators as potential therapeutic targets.