A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
D Martin-Zanca, SH Hughes, M Barbacid - Nature, 1986 - nature.com
D Martin-Zanca, SH Hughes, M Barbacid
Nature, 1986•nature.comA biologically active complementary DNA clone of a transforming gene present in a human
colon carcinoma contains gene sequences of both tropomyosin and a previously unknown
protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene
seems to have been formed by a somatic rearrangement that replaced the extracellular
domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle
tropomyosin molecule.
colon carcinoma contains gene sequences of both tropomyosin and a previously unknown
protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene
seems to have been formed by a somatic rearrangement that replaced the extracellular
domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle
tropomyosin molecule.
Abstract
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.
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