Effects of leukotriene B4 and prostaglandin E2 on the differentiation of murine Foxp3+ T regulatory cells and Th17 cells
H Chen, J Qin, P Wei, J Zhang, Q Li, L Fu, S Li… - … and essential fatty acids, 2009 - Elsevier
Leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) are shown to be potent
immunoregulatory lipid mediators. Here, we examined the effects of LTB4 and PGE2 on the
differentiation of immunosuppressive CD4+ CD25+ Foxp3+ T regulatory cells (Treg) and pro-
inflammatory IL-17-producing cells (Th17) from murine naļve CD4+ T cells. Using MACS-
purified murine CD4+ CD62L+ naļve T cells, we found that three days later in the presence
of TGF-β1,(28.65±6.83)% cells were converted into Treg cells, the mRNA expression of the …
immunoregulatory lipid mediators. Here, we examined the effects of LTB4 and PGE2 on the
differentiation of immunosuppressive CD4+ CD25+ Foxp3+ T regulatory cells (Treg) and pro-
inflammatory IL-17-producing cells (Th17) from murine naļve CD4+ T cells. Using MACS-
purified murine CD4+ CD62L+ naļve T cells, we found that three days later in the presence
of TGF-β1,(28.65±6.83)% cells were converted into Treg cells, the mRNA expression of the …