[HTML][HTML] Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer …
JW Lee, JH Kim - Journal of Biological Chemistry, 2013 - ASBMB
The majority of prostate cancer-related deaths are associated with advanced and metastatic
malignancies. Although anoikis resistance has been recognized as one of the hallmarks of
metastatic prostate malignancies, the molecular events that cause anoikis resistance are
poorly understood. In this study, we found that the detachment of PC-3 prostate cancer cells
caused a time-dependent increase in the expression level of the leukotriene B 4 receptor-2
(BLT2) and that BLT2 played a critical role in establishing anoikis resistance in these cells …
malignancies. Although anoikis resistance has been recognized as one of the hallmarks of
metastatic prostate malignancies, the molecular events that cause anoikis resistance are
poorly understood. In this study, we found that the detachment of PC-3 prostate cancer cells
caused a time-dependent increase in the expression level of the leukotriene B 4 receptor-2
(BLT2) and that BLT2 played a critical role in establishing anoikis resistance in these cells …