[HTML][HTML] Leukotriene B4 augments and restores FcγRs-dependent phagocytosis in macrophages

F Okamoto, K Saeki, H Sumimoto, S Yamasaki… - Journal of Biological …, 2010 - ASBMB
Phagocytosis by macrophages is essential for host defense, ie preventing invasion of
pathogens and foreign materials. Macrophages engulf immunoglobulin G (IgG)-opsonized
particles through the action of the receptors for the Fc of IgG (FcγRs). Leukotriene B 4 (LTB
4) is a classical lipid chemoattractant derived from arachidonic acid. Leukotriene B 4
receptor 1 (BLT1), a high affinity LTB 4 receptor, is expressed in a variety of immune cells
such as neutrophils, macrophages, and dendritic cells. Although LTB 4 has been shown to …