[HTML][HTML] Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary …
TC Beller, A Maekawa, DS Friend, KF Austen… - Journal of Biological …, 2004 - ASBMB
The cysteinyl leukotrienes (cys-LTs) mediate both acute and chronic inflammatory
responses in mice, as demonstrated by the attenuation of the IgE/antigen-mediated increase
in microvascular permeability and of bleomycin-induced pulmonary fibrosis, respectively, in
a strain with targeted disruption of leukotriene C 4 synthase to prevent cys-LT synthesis. Our
earlier finding that the acute, but not the chronic, injury was attenuated in a strain with
targeted disruption of the cysteinyl leukotriene 1 (CysLT 1) receptor suggested that the …
responses in mice, as demonstrated by the attenuation of the IgE/antigen-mediated increase
in microvascular permeability and of bleomycin-induced pulmonary fibrosis, respectively, in
a strain with targeted disruption of leukotriene C 4 synthase to prevent cys-LT synthesis. Our
earlier finding that the acute, but not the chronic, injury was attenuated in a strain with
targeted disruption of the cysteinyl leukotriene 1 (CysLT 1) receptor suggested that the …