[HTML][HTML] Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine

H Inbe, S Watanabe, M Miyawaki, E Tanabe… - Journal of Biological …, 2004 - ASBMB
AMP and adenosine are found in all cell types and can be released by cells or created
extracellularly from the breakdown of ATP and ADP. We have identified an orphan G protein-
coupled receptor with homology to the P2Y family of nucleotide receptors that can respond
to both AMP and adenosine. Based on its ability to functionally bind the nucleotide AMP, we
have named it P2Y15. Upon stimulation, P2Y15 induces both Ca 2+ mobilization and cyclic
AMP generation, suggesting coupling to at least two different G proteins. It is highly …