[PDF][PDF] Circuits controlling energy balance and mood: inherently intertwined or just complicated intersections?

C Liu, S Lee, JK Elmquist - Cell metabolism, 2014 - cell.com
C Liu, S Lee, JK Elmquist
Cell metabolism, 2014cell.com
Recent reports of adverse psychiatric events from seemingly different types of weight loss
therapies highlight a previously underestimated overlap between CNS circuits that control
energy balance and those that regulate mood. In this Perspective, we discuss a few potential
brain sites where the homeostatic and the hedonic pathways may intersect and suggest that
a better understanding of both pathways is necessary for the development of more effective
and safer antiobesity therapies.
Recent reports of adverse psychiatric events from seemingly different types of weight loss therapies highlight a previously underestimated overlap between CNS circuits that control energy balance and those that regulate mood. In this Perspective, we discuss a few potential brain sites where the homeostatic and the hedonic pathways may intersect and suggest that a better understanding of both pathways is necessary for the development of more effective and safer antiobesity therapies.
cell.com