Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II–induced inflammation
M Jurewicz, DH McDermott, JM Sechler… - Journal of the …, 2007 - journals.lww.com
The renin-angiotensin system (RAS) plays an important role in the regulation of
inflammation and in the progression of chronic kidney disease. Accumulation of
inflammatory cells into the renal parenchyma has been a hallmark of chronic kidney
disease; however, little is known concerning the presence and the function of RAS elements
in T and natural killer (NK) cells. Here is reported a co-stimulatory effect of angiotensin II
(AngII) by showing an augmentation of mitogen and anti–CD3-stimulated T and NK cell …
inflammation and in the progression of chronic kidney disease. Accumulation of
inflammatory cells into the renal parenchyma has been a hallmark of chronic kidney
disease; however, little is known concerning the presence and the function of RAS elements
in T and natural killer (NK) cells. Here is reported a co-stimulatory effect of angiotensin II
(AngII) by showing an augmentation of mitogen and anti–CD3-stimulated T and NK cell …