[HTML][HTML] SGK1 phosphorylation of IκB kinase α and p300 up-regulates NF-κB activity and increases N-methyl-D-aspartate receptor NR2A and NR2B expression

DJC Tai, CC Su, YL Ma, EHY Lee - Journal of Biological Chemistry, 2009 - ASBMB
Serum-and glucocorticoid-inducible kinase 1 (SGK1) is a downstream target of
phosphatidylinositol 3-kinase signaling, and it regulates various cellular and physiological
functions, but the SGK1 substrate proteins and genes regulated by SGK1 are less known.
Here we have identified IκB kinase α (IKKα) as a novel substrate of SGK1 by using
biochemical and bioinformatic approaches. SGK1 directly phosphorylates IKKα at Thr-23
and indirectly activates IKKα at Ser-180. Furthermore, SGK1 enhanced nuclear factor κB (NF …