[HTML][HTML] Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes

DC Thurmond, BP Ceresa, S Okada… - Journal of Biological …, 1998 - ASBMB
Insulin stimulates glucose transporter (GLUT) 4 vesicle translocation from intracellular
storage sites to the plasma membrane in 3T3L1 adipocytes through a VAMP2-and syntaxin
4-dependent mechanism. We have observed that Munc18c, a mammalian homolog of the
yeast syntaxin-binding protein n-Sec1p, competed for the binding of VAMP2 to syntaxin 4.
Consistent with an inhibitory function for Munc18c, expression of Munc18c, but not the
related Munc18b isoform, prevented the insulin stimulation of GLUT4 and IRAP/vp165 …