Infiltration of immune T cells in the brain of mice with herpes simplex virus-induced encephalitis
WL Chan, T Javanovic, ML Lukic - Journal of neuroimmunology, 1989 - Elsevier
Herpes simplex virus (HSV) infection of mice can induce viral encephalitis. Using two-
fluorochrome immunofluorescence, our present study shows that though there is extensive
myelin loss and necrosis in the brain stem of mice with HSV encephalitis, only some
oligodendrocytes, astrocytes and microglial cells are infected. T cells that express CD4 or
CD8 and a large number of CD4+, F4/80+ macrophages are present in perivascular
infiltrates close to and in contact with HSV-infected cells in areas of massive myelin loss …
fluorochrome immunofluorescence, our present study shows that though there is extensive
myelin loss and necrosis in the brain stem of mice with HSV encephalitis, only some
oligodendrocytes, astrocytes and microglial cells are infected. T cells that express CD4 or
CD8 and a large number of CD4+, F4/80+ macrophages are present in perivascular
infiltrates close to and in contact with HSV-infected cells in areas of massive myelin loss …