Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem.
Megalin, an endocytic receptor expressed at the apical membranes of proximal tubules,
mediates the nephrotoxicity of aminoglycosides and colistin, key antimicrobials for multidrug-
resistant organisms. The mechanisms underlying the nephrotoxicity induced by vancomycin,
an antimicrobial for methicillin-resistant Staphylococcus aureus, and cisplatin, an important
anticancer drug, are unknown, although the nephrotoxicity of these drugs and gentamicin …