Contrast-induced nephropathy: from pathophysiology to preventive strategies
L Azzalini, V Spagnoli, HQ Ly - Canadian Journal of Cardiology, 2016 - Elsevier
Contrast-induced nephropathy (CIN) is a frequent cause of acute kidney injury in
hospitalized patients. CIN is most commonly defined as either an absolute (≥ 0.5 mg/dL;≥
44 μmol/L) or relative (≥ 25%) increase in serum creatinine levels at 48-72 hours after
exposure to iodinated contrast media (CM). Its occurrence is associated with worsened
clinical outcomes. Patients undergoing cardiac catheterization and percutaneous coronary
intervention are particularly vulnerable to CIN. The complex pathophysiology of CIN involves …
hospitalized patients. CIN is most commonly defined as either an absolute (≥ 0.5 mg/dL;≥
44 μmol/L) or relative (≥ 25%) increase in serum creatinine levels at 48-72 hours after
exposure to iodinated contrast media (CM). Its occurrence is associated with worsened
clinical outcomes. Patients undergoing cardiac catheterization and percutaneous coronary
intervention are particularly vulnerable to CIN. The complex pathophysiology of CIN involves …