Consequences of angiogenesis for tumor progression, metastasis and cancer therapy
JW Rak, BD St Croix, RS Kerbel - Anti-cancer drugs, 1995 - journals.lww.com
The growth of solid tumors to a clinically relevant size is dependent upon an adequate blood
supply. 1 This is achieved by the process of tumor stroma generation where the formation of
new capillaries is a central event. 1, 2 Progressive recruitment of blood vessels to the tumor
site and reciprocal support of tumor expansion by the resulting neovasculature are thought
to result in a self-perpetuating loop helping to drive the growth of solid tumors. 3 The
development of new vasculature also allows an 'evacuation route'for metastatically …
supply. 1 This is achieved by the process of tumor stroma generation where the formation of
new capillaries is a central event. 1, 2 Progressive recruitment of blood vessels to the tumor
site and reciprocal support of tumor expansion by the resulting neovasculature are thought
to result in a self-perpetuating loop helping to drive the growth of solid tumors. 3 The
development of new vasculature also allows an 'evacuation route'for metastatically …