Phospholipase Cγ in Toll-like receptor-mediated inflammation and innate immunity

YS Bae, HY Lee, YS Jung, M Lee, PG Suh - Advances in biological …, 2017 - Elsevier
Among the phospholipase C (PLC) isoforms, PLCγ not only has unique structural
characteristics in terms of harboring SH2 and SH3 domains but also mediates growth factor-
induced signaling pathways. PLCγ isoforms are expressed in several innate immune cell
types, including macrophages, natural killer cells, mast cells, and neutrophils. Stimulation of
Fc receptor or integrin in innate immune cells induces PLCγ activation, which leads to
phosphoinositide hydrolysis and calcium increase. The products of PLCγ activity mediate …