Platelet activating factor: a potential biomarker in acute coronary syndrome?

AVK Palur Ramakrishnan, TP Varghese… - Cardiovascular …, 2017 - Wiley Online Library
AVK Palur Ramakrishnan, TP Varghese, S Vanapalli, NK Nair, MD Mingate
Cardiovascular Therapeutics, 2017Wiley Online Library
Platelet activating factor (PAF) is a potent pro‐inflammatory negotiator that shows distinct
spectrum of biological and pharmacological effects. Importantly, it participates in a wide
range of pathophysiological conditions. In cardiovascular system, PAF has been shown to
have an important role in platelet and neutrophil aggregation, vascular permeability,
microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells, and
initiation and progression of atherosclerosis. The purpose of this article was to review the …
Summary
Platelet activating factor (PAF) is a potent pro‐inflammatory negotiator that shows distinct spectrum of biological and pharmacological effects. Importantly, it participates in a wide range of pathophysiological conditions. In cardiovascular system, PAF has been shown to have an important role in platelet and neutrophil aggregation, vascular permeability, microvascular leakage, thrombus formation, leukocyte adhesion to the endothelial cells, and initiation and progression of atherosclerosis. The purpose of this article was to review the PAF, a family of lipids that is associated with the pathology of coronary artery diseases due to their association with leading etiological mechanisms such as inflammation, endothelial dysfunction, oxidative and nitrosative stress, and platelet reactivity. This review further provides information about PAF and its potential role as a key contributor to the pathogenesis of cardiovascular disorders.
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