Platelet-activating factor as a mediator of allergic disease

PJ Barnes, KF Chung, CP Page - Journal of allergy and clinical …, 1988 - Elsevier
Many different mediators have been implicated in allergic responses and allergic diseases.
14 It is becoming increasingly apparent that no single mediator can account for allergic
diseases, such as asthma, rhinitis, eczema, or anaphylaxis, and that the clinical
manifestation depends on a complex interaction of mediators that are released from a
variety of cells. Although previous research concentrated on the mast cell as the key cell in
allergic reactions, it now appears likely that other inflammatory cells, such as macrophages …