[HTML][HTML] The phospholipase A1 activity of lysophospholipase AI links platelet activation to LPA production during blood coagulation [S]

AL Bolen, AP Naren, S Yarlagadda… - Journal of lipid …, 2011 - ASBMB
Platelet activation initiates an upsurge in polyunsaturated (18: 2 and 20: 4) lysophosphatidic
acid (LPA) production. The biochemical pathway (s) responsible for LPA production during
blood clotting are not yet fully understood. Here we describe the purification of a
phospholipase A 1 (PLA 1) from thrombin-activated human platelets using sequential
chromatographic steps followed by fluorophosphonate (FP)-biotin affinity labeling and
proteomics characterization that identified acyl-protein thioesterase 1 (APT1), also known as …