Signal-activated phospholipases are a recent focus of the rapidly growing field of lipid
signaling. The extent of their impact on the pathways regulating diverse cell functions is
beginning to be appreciated. A critical step in inflammation is the attraction of leukocytes to
injured or diseased tissue. Chemotaxis of leukocytes, a requisite process for monocyte and
neutrophil extravasation from the blood into tissues, is a critical step for initiating and
maintaining inflammation in both acute and chronic settings. Recent studies have identified …