Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells
DP Leone, S téphane Genoud, S Atanasoski… - Molecular and Cellular …, 2003 - Elsevier
Inducible transgenesis provides a valuable technique for the analysis of gene function in
vivo. We report the generation and characterization of mouse lines carrying glia lineage-
specific transgenes expressing an improved variant of the tamoxifen-inducible Cre
recombinase, CreERT2, where the recombinase is fused to a mutated ligand binding
domain of the human estrogen receptor. Using a PLP-CreERT2 transgene, we have
generated mice that show specific inducible Cre function, as analyzed by cross-breeding …
vivo. We report the generation and characterization of mouse lines carrying glia lineage-
specific transgenes expressing an improved variant of the tamoxifen-inducible Cre
recombinase, CreERT2, where the recombinase is fused to a mutated ligand binding
domain of the human estrogen receptor. Using a PLP-CreERT2 transgene, we have
generated mice that show specific inducible Cre function, as analyzed by cross-breeding …