[HTML][HTML] Noninvasive imaging of CCR2+ cells in ischemia-reperfusion injury after lung transplantation
Y Liu, W Li, HP Luehmann, Y Zhao, L Detering… - American Journal of …, 2016 - Elsevier
Ischemia-reperfusion injury–mediated primary graft dysfunction substantially hampers short-
and long-term outcomes after lung transplantation. This condition continues to be diagnosed
based on oxygen exchange parameters as well as radiological appearance, and therapeutic
strategies are mostly supportive in nature. Identifying patients who may benefit from targeted
therapy would therefore be highly desirable. Here, we show that CC chemokine receptor
type 2 (CCR2) expression in murine lung transplant recipients promotes monocyte …
and long-term outcomes after lung transplantation. This condition continues to be diagnosed
based on oxygen exchange parameters as well as radiological appearance, and therapeutic
strategies are mostly supportive in nature. Identifying patients who may benefit from targeted
therapy would therefore be highly desirable. Here, we show that CC chemokine receptor
type 2 (CCR2) expression in murine lung transplant recipients promotes monocyte …