[HTML][HTML] Role of CXCR3-induced donor T-cell migration in acute GVHD
U Duffner, B Lu, GC Hildebrandt, T Teshima… - Experimental …, 2003 - Elsevier
OBJECTIVE: The chemokine receptor CXCR3 has an important role in the migration of
effector T cells. To investigate the role of CXCR3 on donor cells in acute graft vs host
disease (GVHD) we used a well-defined experimental bone marrow transplantation (BMT)
model where acute GVHD is mediated by donor CD8+ T cells against minor
histocompatibility antigens. METHODS: Lethally irradiated C3H. SW recipients were
transplanted from either wild-type B6 or CXCR3−/− B6 donors. Donor T-cell expansion was …
effector T cells. To investigate the role of CXCR3 on donor cells in acute graft vs host
disease (GVHD) we used a well-defined experimental bone marrow transplantation (BMT)
model where acute GVHD is mediated by donor CD8+ T cells against minor
histocompatibility antigens. METHODS: Lethally irradiated C3H. SW recipients were
transplanted from either wild-type B6 or CXCR3−/− B6 donors. Donor T-cell expansion was …