Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count

TW Schacker, C Reilly, GJ Beilman, J Taylor, D Skarda… - Aids, 2005 - journals.lww.com
TW Schacker, C Reilly, GJ Beilman, J Taylor, D Skarda, D Krason, M Larson, AT Haase
Aids, 2005journals.lww.com
The structure of lymphatic tissues is an important component of lymphatic tissue T-cell
homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts
the niche and limits the size of the resident CD4 cell population. In this report we show that a
single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the
peripheral CD4 cell pool with HAART (P< 0.001). This suggests that collagen-targeted
therapies might be of benefit.
Abstract
The structure of lymphatic tissues is an important component of lymphatic tissue T-cell homeostasis. Collagen deposition in lymphatic tissues (common in HIV infection) disrupts the niche and limits the size of the resident CD4 cell population. In this report we show that a single measurement of lymphatic tissue collagen predicts the magnitude of recovery of the peripheral CD4 cell pool with HAART (P< 0.001). This suggests that collagen-targeted therapies might be of benefit.
Lippincott Williams & Wilkins