[HTML][HTML] Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-κB activation
M Zeyda, MD Säemann, KM Stuhlmeier… - Journal of Biological …, 2005 - ASBMB
Polyunsaturated fatty acids (PUFAs) modulate immune responses leading to clinically
significant beneficial effects in a variety of inflammatory disorders. PUFA effects on T cells
have been extensively studied, but their influence on human dendritic cells (DCs), which are
the most potent antigen-presenting cells and play a key role in initiating immune responses,
has not been elucidated so far. Here we show that PUFAs of the n-3 and n-6 series
(arachidonic and eicosapentaenoic acid) affect human monocyte-derived DC differentiation …
significant beneficial effects in a variety of inflammatory disorders. PUFA effects on T cells
have been extensively studied, but their influence on human dendritic cells (DCs), which are
the most potent antigen-presenting cells and play a key role in initiating immune responses,
has not been elucidated so far. Here we show that PUFAs of the n-3 and n-6 series
(arachidonic and eicosapentaenoic acid) affect human monocyte-derived DC differentiation …