[HTML][HTML] Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes
KA Scoggan, PJ Jakobsson… - Journal of Biological …, 1997 - ASBMB
Microsomal glutathione S-transferase-II (GST-II) has recently been discovered and
characterized as a member of the 5-lipoxygenase-activating protein (FLAP)/5 (S)-hydroxy-6
(R)-S-glutathionyl-7, 9-trans-11, 14-cis-eicosatetraenoic acid (LTC 4) synthase gene family,
which also includes microsomal glutathione S-transferase-I (GST-I) as a distant member of
this gene family. This new enzyme is unique as it is the only member of this family capable of
efficiently conjugating reduced glutathione to both 5, 6-oxido-7, 9, 11, 14-eicosatetraenoic …
characterized as a member of the 5-lipoxygenase-activating protein (FLAP)/5 (S)-hydroxy-6
(R)-S-glutathionyl-7, 9-trans-11, 14-cis-eicosatetraenoic acid (LTC 4) synthase gene family,
which also includes microsomal glutathione S-transferase-I (GST-I) as a distant member of
this gene family. This new enzyme is unique as it is the only member of this family capable of
efficiently conjugating reduced glutathione to both 5, 6-oxido-7, 9, 11, 14-eicosatetraenoic …