The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target
J Chu, D Praticò - Brain research bulletin, 2016 - Elsevier
Alzheimer's disease (AD) is an age-related, neurodegenerative disorder characterized by
cognitive impairment with memory loss, extracellular amyloid beta (Aβ) peptides
aggregation, and intracellular hyper-phosphorylated tau neurofibrillary tangles (NFT)
accumulation. Although the 5-lipoxygenase (5LO) protein enzyme is well known as an
important modulators of oxidation and inflammation, recent work has highlighted the new
hypothesis that this pathway may play a direct role in AD pathogenesis. In this review article …
cognitive impairment with memory loss, extracellular amyloid beta (Aβ) peptides
aggregation, and intracellular hyper-phosphorylated tau neurofibrillary tangles (NFT)
accumulation. Although the 5-lipoxygenase (5LO) protein enzyme is well known as an
important modulators of oxidation and inflammation, recent work has highlighted the new
hypothesis that this pathway may play a direct role in AD pathogenesis. In this review article …