Cloning and characterization of LAG1, a longevity-assurance gene in yeast.
NP D'mello, AM Childress, DS Franklin, SP Kale… - Journal of Biological …, 1994 - ASBMB
The yeast Saccharomyces cerevisiae has a finite life span that is measured by the number of
times the individual cell divides. The gene coding for one of several transcripts that are
differentially expressed during the replicative life span has been cloned. The nucleotide
sequence revealed an open reading frame capable of encoding a transmembrane protein of
411 amino acids that displays no significant similarities to any known proteins. Nevertheless,
sequences similar to this gene were found in several mammals, including humans. The …
times the individual cell divides. The gene coding for one of several transcripts that are
differentially expressed during the replicative life span has been cloned. The nucleotide
sequence revealed an open reading frame capable of encoding a transmembrane protein of
411 amino acids that displays no significant similarities to any known proteins. Nevertheless,
sequences similar to this gene were found in several mammals, including humans. The …