Cellular senescence in the glaucomatous outflow pathway

PB Liton, P Challa, S Stinnett, C Luna, DL Epstein… - Experimental …, 2005 - Elsevier
The mechanisms responsible for the progressive malfunction of the trabecular meshwork
(TM)–Schlemm's canal (SC) conventional outflow pathway tissue in primary open angle
glaucoma (POAG) are still not fully understood. To determine whether POAG is
characterized by an accumulation of senescent cells, similar to what has been described in
other diseases, we have compared the levels of the senescence marker senescence-
associated-β-galactosidase (SA-β-gal) in the outflow pathway cells of POAG and age …