[HTML][HTML] Ikaros silences T-bet expression and interferon-γ production during T helper 2 differentiation

RM Thomas, C Chen, N Chunder, L Ma, J Taylor… - Journal of biological …, 2010 - ASBMB
CD4+ T cells can be instructed by nonantigen-specific signals to differentiate into
functionally distinct lineages with mutually exclusive patterns of cytokine production. The
molecular events that drive interferon-γ (IFNγ) production during Th1 development are well
understood, but mechanisms that silence this cytokine during Th2 polarization are not clear.
In this study, we find that the tbx21 gene encoding the Th1 master regulator T-bet is a direct
target of the transcriptional repressor Ikaros. In Th2 cells, which do not express T-bet, strong …