[HTML][HTML] Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor

JF Maddox, M Hachicha, T Takano, NA Petasis… - Journal of Biological …, 1997 - ASBMB
Lipoxins (LX) are bioactive eicosanoids that activate human monocytes and inhibit
neutrophils. LXA 4 is rapidly converted by monocytes to inactive products, and to resist
metabolism, synthetic analogs of LXA 4 were designed. Here, we examined the bioactivity of
several LXA 4 analogs in monocytes and found, for chemotaxis, 15 (R/S)-methyl-LXA 4 and
15-epi-LXA 4 were equal in activity, and 16-phenoxy-LXA 4 was more potent than native
LXA 4. Both 15 (R/S)-methyl-LXA 4 and 16-phenoxy-LXA 4 were∼ 1 log molar more potent …