Vascular and soft tissue calcification contributes to cardiovascular morbidity and mortality in
both the general population and CKD. Because calcium and phosphate serum
concentrations are near supersaturation, the balance of inhibitors and promoters critically
influences the development of calcification. An assay that measures the overall propensity
for calcification to occur in serum may have clinical use. Here, we describe a nanoparticle-
based assay that detects, in the presence of artificially elevated calcium and phosphate …