[HTML][HTML] Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis

SN Flier, H Tanjore, EG Kokkotou, H Sugimoto… - Journal of Biological …, 2010 - ASBMB
Intestinal fibrosis is a major complication of Crohn disease (CD), but the precise mechanism
by which it occurs is incompletely understood. As a result, specific therapies to halt or even
reverse fibrosis have not been explored. Here, we evaluated the contribution of epithelial to
mesenchymal transition (EMT) to intestinal fibrosis associated with a mouse model of CD
and also human inflammatory bowel disease. Mice administered intrarectal 2, 4, 6-
trinitrobenzene sulfonic acid (TNBS) develop inflammation and fibrosis that resembles CD …