Distinct patterns of cytokine gene suppression by the equivalent effective doses of cyclosporine and tacrolimus in rat heart allografts
H Jiang, X Yang, RN Soriano, T Fujimura, K Krishnan… - Immunobiology, 2000 - Elsevier
In vitro studies of the mode of action of cyclosporine (CsA) and tacrolimus have indicated
that both drugs produce immunosuppression by a quite similar cellular and molecular
mechanism to block T cell receptor emanated transcriptional activation of interleukin (IL)-2
and other cytokine genesHerein, we show that there are distinct patterns of cytokine gene
expression in rat heart allografts under equivalent effective doses (“optimal dose”) of CsA
and tacrolimusThe optimal doses of CsA (10 mg/kg/day) and tacrolimus (3.2 mg/kg/day) …
that both drugs produce immunosuppression by a quite similar cellular and molecular
mechanism to block T cell receptor emanated transcriptional activation of interleukin (IL)-2
and other cytokine genesHerein, we show that there are distinct patterns of cytokine gene
expression in rat heart allografts under equivalent effective doses (“optimal dose”) of CsA
and tacrolimusThe optimal doses of CsA (10 mg/kg/day) and tacrolimus (3.2 mg/kg/day) …