The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

P Georgel, M Radosavljevic, C Macquin… - Molecular immunology, 2011 - Elsevier
P Georgel, M Radosavljevic, C Macquin, S Bahram
Molecular immunology, 2011Elsevier
As opposed to the well established role of MHC-linked, polymorphic, class I (MHC-I) genes
in adaptive immunity, a universal role for non-conventional MHC-I is unknown, thus
requiring a case-by-case study. The MHC unlinked, monomorphic, but β2microglobulin
(β2m)-associated “MHC class I related” MR1 molecule interacts with a semi-invariant TCR.
The pathophysiology of this interaction or more importantly of this peculiar MHC-I remains
mostly unknown. Recently it was shown that β2m deficient mice were more susceptible to …
As opposed to the well established role of MHC-linked, polymorphic, class I (MHC-I) genes in adaptive immunity, a universal role for non-conventional MHC-I is unknown, thus requiring a case-by-case study. The MHC unlinked, monomorphic, but β2microglobulin (β2m)-associated “MHC class I related” MR1 molecule interacts with a semi-invariant TCR. The pathophysiology of this interaction or more importantly of this peculiar MHC-I remains mostly unknown. Recently it was shown that β2m deficient mice were more susceptible to infection by Klebsiella pneumoniae, a widely spread Gram-negative bacteria that causes diverse and often severe ailments in man. Here we demonstrate, using both an in vivo imaging system and survival tests, the increased susceptibility to K. pneumoniae (but not to several other Gram negative bacteria) of MR1 deficient mice. This is accompanied by a consequent change in body temperature and systemic cytokine profile. Hence MR1 controls K. pneumoniae infection in vivo.
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